Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats
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چکیده
منابع مشابه
Phosphorylated neuronal nitric oxide synthase in neuropathic pain in rats.
Neuropathic pain caused by nervous system damage or system dysfunction. The pathogenesis and the mechanism underlying neuropathic pain remains unclear. The only known neurobiological component involved in the neuropathic pain is nitric oxide (NO). NO is synthesized by nitric oxide synthase (nNOS) from L-arginine and oxygen. nNOS is involved in the inflammatory pain and neuropathic pain. In this...
متن کاملNeonatal exposure to sevoflurane causes apoptosis and reduces nNOS protein expression in rat hippocampus.
A growing number of studies have shown that commonly used anesthetic agents may cause neurohistopathological changes and persistent behavioral impairments in the developing brain. The effects of sevoflurane, a widely used substance in pediatric anesthesia, on the developing brain have not been thoroughly analyzed thus far. In this study, Sprague-Da...
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BACKGROUND Nitric oxide (NO) synthesized within sinoatrial cells recently has been shown to participate in the autonomic control of heart rate. We hypothesized that NO in the neuronal cells in the heart was increased and parasympathetically regulated heart rate after myocardial infarction (MI). METHODS AND RESULTS We examined heart rate dynamics and neuronal NO synthase (nNOS) expression and ...
متن کاملExpression of neuronal nitric oxide synthase in the developing superficial layers of the rat superior colliculus.
We investigated the level of expression of neuronal nitric oxide synthase (nNOS) in the retinorecipient layers of the rat superior colliculus during early postnatal development. Male and female Lister rats ranging in age between the day of birth (P0) and the fourth postnatal week were used in the present study. Two biochemical methods were used, i.e., in vitro measurement of NOS specific activi...
متن کاملComparison of inducible nitric oxide synthase activity in pancreatic islets of young and aged rats
Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2012
ISSN: 0007-0912
DOI: 10.1093/bja/aes121